Publications

Structural and biosynthetic studies on eremophilenols related to the phytoalexin capsidiol, produced by Botrytis cinereaIvonne Suárez, Gesiane da Silva, Raphael Conti, Cristina Pinedo, Javier Moraga, Javier Barúa, Ana L. Leandrini de Oliveira, Josefina Aleu, Rosa Durán-Patrón, Antonio J. Macías-Sánchez, James R. Hanson, Mônica Tallarico, Rosario Hernández-Galán, Isidro G. Collado. Phytochemistry (2018), 154, 10-18 Índice impacto: 3.186      Posición de la revista  34/222                    Q1

Biosynthesis of abscisic acid in fungi: Identification of a sesquiterpene cyclase as the key enzyme in Botrytis cinerea. Inmaculada Izquierdo-Bueno, Victoria E. González-Rodríguez, Adeline Simon, Bérengère Dalmais, Jean-Marc Pradier, Pascal Le Pêcheur, Alex Mercier, Anne-Sophie Walker, Carlos Garrido, Isidro González Colladoand Muriel Viaud.. Environmental Microbiology (2018),….                                    Índice de Impacto: 4.974         Posición de la revista:  21/125     (Microbiology)      Q1

The sesquiterpene botrydial from Botrytis cinerea induces phosphatidic acid production in timato cell suspensions. Juan Martín D´Ambrosio, Gabriela Gonorazky, Daniela J. Sueldo, Javier Moraga, Andres Arruebarrena Di Palma, Lorenzo Lamattina, Isidro G. Collado y Ana María Laxalt. Planta, (2018), D.O.I.= /10.1007/s00425-018-2843-8                                                                                             Q1

Metabolism of Antifungal Thiochroman-4-ones by Trichoderma viride and Botrytis cinerea. Cristina Pinedo-Rivilla, Isidro G. Collado, and Josefina Aleu.  Journal Natural Products (2018), in press DOI: 10.1021/acs.jnatprod.7b00298                               Índice impacto: 3.885              Posición de la revista en el área: 21/222          D1

Relevance of the deletion of the Tatri4 gene in the secondary metabolome of Trichoderma arundinaceum. Inmaculada Izquierdo-Bueno, Javier Moraga, Rosa E. Cardoza, Laura Lindo, James R. Hanson, Santiago Gutiérrez  and Isidro G. Collado Organic & Biomolecular Chemistry, (2018), 16, 2955–2965                           Q2

Cp2Ti(III)Cl and Analogues as Sustainable Templates in Organic Synthesis. Botubol-Ares, José Manuel; Durán-Peña, María Jesús; Hanson, James R.; Hernández-Galán, Rosario; Collado, Isidro G.  Synthesis (2018), 50, 2163-2180.            Q2

The formation of sesquiterpenoid presilphiperfolane and cameroonane metabolites in the Bcbot4 null mutant of Botrytis cinerea. Gabriel Franco dos Santos, Javier Moraga, Jacqueline A. Takahashi, Muriel Viaud, James R. Hanson, Rosario Hernández Galán and Isidro G. Collado.                                                                               Organic and Biomolecular Chemistry, (2017), 15, 5357–5363.

Mild Epoxidation of Allylic Alcohols Catalyzed by Titanium (III) Complexes: Selectivity and Mechanism. J. M. Botubol-Ares, J. R. Hanson, R. Hernández-Galán and I. G. Collado. ACS Omega (2017), 2, 3083−3090

Genetic and Molecular Basis of Botrydial Biosynthesis: Connecting Cytochrome P450-Encoding Genes to Biosynthetic Intermediates. Javier Moraga, Bérengère Dalmais, Inmaculada Izquierdo-Bueno, Josefina Aleu, James R. Hanson, Rosario Hernández-Galán, Muriel Viaud, and Isidro G. Collado*.                         ACS Chemical Biology (2016), 11(10), 2838-2846

Trichothecenes and aspinolides produced by Trichoderma arundinaceum regulate expression of Botrytis cinerea genes involved in virulence and growth. Mónica G. Malmierca, Inmaculada Izquierdo-Bueno, Susan P. McCormick, Rosa E. Cardoza,Nancy J. Alexander, Javier Barua, Laura Lindo, Pedro A. Casquero, Isidro G. Collado, Enrique Monte and Santiago Gutierrez. Environmental Microbiology (2016) 18(11), 3991-4004

Chemically Induced Cryptic Sesquiterpenoids and Expression of Sesquiterpene Cyclases in Botrytis cinerea Revealed New Sporogenic (+)-4-Epieremophil-9-en-11-ols. Cristina Pinedo, Javier Moraga, Javier Barua, Victoria E. González-Rodríguez, Josefina Aleu, Rosa Durán-Patrón, Antonio J. Macías-Sánchez, James R. Hanson, Muriel Viaud, Rosario Hernández-Galán, Carlos Garrido, and Isidro G. Collado. ACS Chemical Biology (2016), 11, 1391-1400.

The botrydial biosynthetic gene cluster of Botrytis cinerea displays a bipartite genomic structure and is positively regulated by the putative Zn(II)2Cys6 transcription factor BcBot6. Porquier, Antoine; Morgant, Guillaume; Moraga, Javier; Dalmais, Berengere; Luyten, Isabelle; Simon, Adeline; Pradier, Jean-Marc; Amselem, Joelle; Collado, Isidro Gonzalez; Viaud, Muriel.Fungal Genetics and Biology (2016), 96, 33-46.

Botrydial and botcinins produced by Botrytis cinerea regulate the expression of Trichoderma arundinaceum genes involved in trichothecene biosynthesis. Mónica G. Malmierca , Inmaculada Izquierdo-Bueno, Susan P. McCormick, Rosa E. Cardoza, Nancy J. Alexander, Javier Moraga, Eriston V. Gomes, Robert H. Proctor, Isidro G. Collado, Enrique Monte and Santiago Gutiérrez. Molecular Plant Pathology (2016) 17(7) , 1017–1031.

Efficient O-acylation of alcohols and phenol using Cp2TiCl as a reaction promoter. M. J. Durán-Peña,  J. M. Botubol-Ares, J. R. Hanson, R. Hernández-Galán and I. G. Collado. European Journal of Organic Chemistry, (2016) 3584-3591.

Chemoselective and stereoselective lithium carbenoid mediated cyclopropanation of acyclic allylic alcohols. M. J. Durán-Peña,  M. E. Flores-Giubi, J. M. Botubol-Ares, L. M. Harwood, I. G. Collado, A.J. Macías-Sánchez and R. Hernández-Galán. Organic and Biomolecular Chemistry, (2016), 14, 2731-2741.

The synthesis of 3-hydroxy-2,4,8-trimethyldec-8-enolides and an approach to 3,4-dihydroxy-2,4,6,8-tetramethyldec-8-enolide. Botubol-Ares, Jose Manuel; Duran-Pena, Maria Jesus; Macias-Sanchez, Antonio J.; Hanson, James R.; Collado, Isidro G.; Hernandez-Galan, Rosario. Organic & Biomolecular Chemistry (2015), 13(2), 465-476.

 Unexpected mild protection of alcohols as 2-O-THF and 2-O-THP ethers catalysed by Cp2TiCl reveal an intriguing role of the solvent in the single electron transfer reaction. M. J. Durán-Peña,  J. M. Botubol-Ares, J. R. Hanson, R. Hernández-Galán and I. G. Collado. European Journal of Organic Chemistry (2015) 6333-634.

 Titanium carbenoid-mediated cyclopropanation of allylic alcohols: selectivity and mechanism. M. J. Durán-Peña,  J. M. Botubol-Ares, J. R. Hanson, R. Hernández-Galán and I. G. Collado. Organic and  Biomolecular Chemistry (2015) 13, 6325-6332.

Biological activity of natural sesquiterpenoids containing a gem-dimethylcyclopropane unit. Duran-Pena, Maria Jesus; Botubol Ares, Jose Manuel; Hanson, James R.; Collado, Isidro G.; Hernandez-Galan, Rosario.  Natural Product Reports (2015), 32, 1236-1248.

Novel aspinolide production by Trichoderma arundinaceum with a potential role in Botrytis cinerea antagonistic activity and plant defense priming. M.G. Malmierca, J. Barua, S.P. McCormick, I. Izquierdo‐Bueno, R.E. Cardoza, N.J. Alexander, R. Hermosa, I.G. Collado, E. Monte, S. Gutiérrez. Environmental Microbiology (2015), 7(4), 1103-1118; · 6.24 Impact Factor

The Asymmetric Total Synthesis of Cinbotolide: A Revision of the Original Structure. Botubol-Ares, Jose Manuel; Duran-Pena, Maria Jesus; Macias-Sanchez, Antonio J.; Hanson, James R.; Collado, Isidro G.; Hernandez-Galan, Rosario. Journal of Organic Chemistry (2014), 79(23), 11349-11358.

 Biologically active diterpenes containing a gem-dimethylcyclopropane subunit: an intriguing source of PKC modulators. Duran-Pena, Maria Jesus; Botubol Ares, Jose Manuel; Collado, Isidro G.; Hernandez-Galan, Rosario., Natural Product Reports (2014), 31(7), 940-952.

Exploring mutasynthesis to increase structural diversity in the synthesis of highly oxygenated polyketide lactones. Botubol-Ares, J. M.; Duran-Pena, M. J.; Macias-Sanchez, A. J.; Hanson, J. R.; Collado, I. G.; Hernandez-Galan, R., Organic & Biomolecular Chemistry (2014), 12(28), 5304-5310.

Stereoselective Synthesis and Absolute Configuration Determination of Xylariolide A, José Manuel Botubol Antonio J. Macías-Sánchez, Isidro G. Collado, and Rosario Hernández-Galán. Eur. J. Org. Chem. (2013), 2420–2427

A shared biosynthetic pathway for botcinins and botrylactones revealed through gene deletion. Michelli Massaroli, Javier Moraga, Dr. Keyller Bastos Borges, Jacinto Ramirez-Fernández, Dr. Muriel Viaud, Prof. Dr. Isidro González Collado, Dr. Rosa Durán-Patrón, Prof. Dr. Rosario Hernández-Galán. ChemBioChem, (2013), 14, 132-136

 Chemical genetics strategies for identification of molecular targets. Jose Manuel Botubol Ares, Durán Peña, Mº Jesus, Hernández Galán, Rosario; Collado, Isidro G., Phytochemistry Reviews, (2013) 12, 895-914.

Phytotoxic activity and metabolism of Botrytis cinerea and structure-activity relationships of isocaryolane derivatives; Ascari, Jociani; Boaventura, Maria Amelia Diamantino; Takahashi, Jacqueline Aparecida; Duran-Patron, Rosa; Hernandez-Galan, Rosario; Macias-Sanchez, Antonio J.; Collado, Isidro G.; Journal of Natural Products (2013), 76(6), 1016-1024

Comparative genome analysis of Bacillus spp. and its relationship with bioactive nonribosomal peptide production. A. Hamdache, R. Azarken, A. Lamarti, J. Aleu, I. G. Collado; Phytochemistry Review, (2013), 12, 685-716.;

Terpenoid biotransformations by Mucor species. Eliane de Oliveira Silva, Niege Araçari Jacometti Cardoso Furtado, Josefina Aleu & Isidro González Collado;, Phytochemistry Review, (2013), 12, 857-876

Stereoselective Synthesis and Absolute Configuration Determination of Xylariolide A, José Manuel Botubol Antonio J. Macías-Sánchez, Isidro G. Collado, and Rosario Hernández-Galán. Eur. J. Org. Chem. (2013), 2420–2427

 HPLC Analysis of Midodrine and Desglymidodrine in Culture Medium: Evaluation of Static and Shaken Conditions on the Biotransformation by Fungi. Thiago Barth, Josefina Aleu, Monica Tallarico Pupo, Pierina Sueli Bonato and Isidro G. Collado. Journal of Chromatographic Science 2013;51:460–467

 Relevance of trichothecenes in fungal physiology: Disruption of tri5 in Trichoderma Arundinaceum. Mónica G. Malmierca, Rosa Elena Cardoza, Nancy J. Alexander, Susan P. McCormick, Isidro G. Collado Rosa Hermosa, Enrique Monte, Santiago Gutiérrez. Fungal Genetics and Biology, (2013), 53, 22–33

Natural variation in the VELVET gene bcvel1 affects virulence and light-dependent differentiation in Botrytis cinerea. Schumacher, Julia; Pradier, Jean-Marc; Simon, Adeline; Traeger, Stefanie; Moraga, Javier; Collado, Isidro Gonzalez; Viaud, Muriel; Tudzynski, Bettina. PLoS One (2012), 7(10), e47840.

BcAtf1- A global regulator controls various differentiation processes and phytotoxin production in Botrytis cinerea. Temme Nora; Oeser Birgitt; Massaroli Michelli; Heller Jens; Simon Adeline; Collado Isidro Gonzalez; Viaud Muriel; Tudzynski Paul; Molecular Plant Pathology 2012, 13(7), 704-18.

 The mitogen-activated protein kinase BcSak1 of Botrytis cinerea is required for pathogenic development and has broad regulatory functions beyond stress response. Heller, Jens; Ruhnke, Nadja; Espino, Jose Juan; Massaroli, Michelli; Collado, Isidro Gonzalez; Tudzynski, Paul. Molecular Plant-Microbe Interactions 2012, 25(6), 802-816.

 Biotransformation of clovane derivatives. Whole cell fungi mediated domino synthesis of rumphellclovane A. Gontijo de Souza, Giovanni; Oliveira, Thays Silva; Takahashi, Jacqueline Aparecida; Collado, Isidro Gonzalez; Macias-Sanchez, Antonio Jose; Hernandez-Galan, Rosario.,  Organic & Biomolecular Chemistry 2012, 10(16), 3315-3320.

 Overexpression of the tri 5 Gene: Effect on the expression of the Trichodermin Biosynthetic genes and on Tomato seedlings. A. Tijerino, R. Hermosa, R.E. Cardoza, J. Moraga, M.G. Malmierca, J. Aleu, I.G. Collado, E. Monte y S. Gutiérrez. Toxins, 2011, 3, 1220-1232

 Botrylactone: new interest in an old molecule, review of its absolute configuration and related compounds. Javier Moraga, Cristina Pinedo, Rosa Duran-Patron, Isidro G. Collado, Rosario Hernandez-Galan. Tetrahedron, 2011, 67, 417-420

 Overexpression of the trichodiene synthase gene Tbtri5 increases trichodermin production and antimicrobial activity in Trichoderma brevicompactum. A. Tijerino, R.E. Cardoza, J. Moraga, M.G. Malmierca, F. Vicente, J. Aleu, I.G. Collado, S. Gutiérrez, E. Monte y R. Hermosa. Fungal Genetics and Biology 2011, 48, 285-296.

 Asymmetric synthesis of 1-(4’-chlorophenyl) alcohol derivatives. Study of the detoxification mechanism of 1-(4’-chlorophenyl)-1-cyclopropyl methanol by Botrytis cinerea. C. Pinedo-RiBcAtf1- A global regulator controls various differentiation processes and phytotoxin production in Botrytis cinerea. Temme Nora; Oeser Birgitt; Massaroli Michelli; Heller Jens; Simon Adeline; Collado Isidro Gonzalez; Viaud Muriel; Tudzynski Paul; Molecular Plant Pathology 2012, 13(7), 704-18.

Non-peptide metabolites from Bacillus genus. A. Hamdache, A. Lamarti, J. Aleu y I.G. Collado. J. Nat. Prod. 2011, 74(4), 893-899

 The Botrytis cinerea phytotoxin botcinic acid requires two polyketide synthases for production and has a redundant role in virulence with botrydial. Bérengère Dalmais, Julia Schumacher, Javier Moraga, Pascal le Pecheur, Bettina Tdzynski Isidro Gonzalez Collado, and Muriel Viaud. Molecular Plant Pathology 2011, 12(6), 564-579.

Azaphilones from the endophyte Chaetomium globosum, Borges, Warley S.; Mancilla, Gabriela; Guimaraes, Denise O.; Duran-Patron, Rosa; Collado, Isidro G.; Pupo, Monica T., Journal of Natural Products 2011, 74(5), 1182-1187

Biotransformation of bioactive isocaryolanes by Botrytis cinerea.; Ascari, Jociani; Boaventura, Maria Amelia Diamantino; Takahashi, Jacqueline Aparecida; Duran-Patron, Rosa; Hernandez-Galan, Rosario; Macias-Sanchez, Antonio J.; Collado, Isidro G. Journal of Natural Products 2011, 74(8), 1707-1712.

BcAtf1- A global regulator controls various differentiation processes and phytotoxin production in Botrytis cinerea. Temme Nora; Oeser Birgitt; Massaroli Michelli; Heller Jens; Simon Adeline; Collado Isidro Gonzalez; Viaud Muriel; Tudzynski Paul; Molecular Plant Pathology 2012, 13(7), 704-18.

The mitogen-activated protein kinase BcSak1 of Botrytis cinerea is required for pathogenic development and has broad regulatory functions beyond stress response. Heller, Jens; Ruhnke, Nadja; Espino, Jose Juan; Massaroli, Michelli; Collado, Isidro Gonzalez; Tudzynski, Paul. Molecular Plant-Microbe Interactions 2012, 25(6), 802-816.

Biotransformation of clovane derivatives. Whole cell fungi mediated domino synthesis of rumphellclovane A. Gontijo de Souza, Giovanni; Oliveira, Thays Silva; Takahashi, Jacqueline Aparecida; Collado, Isidro Gonzalez; Macias-Sanchez, Antonio Jose; Hernandez-Galan, Rosario. Organic & Biomolecular Chemistry 2012, 10(16), 3315-3320.

Overexpression of the tri 5 Gene: Effect on the expression of the Trichodermin Biosynthetic genes and on Tomato seedlings. A. Tijerino, R. Hermosa, R.E. Cardoza, J. Moraga, M.G. Malmierca, J. Aleu, I.G. Collado, E. Monte y S. Gutiérrez. Toxins, 2011, 3, 1220-1232

Botrylactone: new interest in an old molecule, review of its absolute configuration and related compounds. Javier Moraga, Cristina Pinedo, Rosa Duran-Patron, Isidro G. Collado, Rosario Hernandez-Galan. Tetrahedron, 2011, 67, 417-420

Overexpression of the trichodiene synthase gene Tbtri5 increases trichodermin production and antimicrobial activity in Trichoderma brevicompactum. A. Tijerino, R.E. Cardoza, J. Moraga, M.G. Malmierca, F. Vicente, J. Aleu, I.G. Collado, S. Gutiérrez, E. Monte y R. Hermosa. Fungal Genetics and Biology 2011, 48, 285-296.

Asymmetric synthesis of 1-(4’-chlorophenyl) alcohol derivatives. Study of the detoxification mechanism of 1-(4’-chlorophenyl)-1-cyclopropyl methanol by Botrytis cinerea. C. Pinedo-Rivilla, A.J. Bustillo, R. Hernández-Galán, J. Aleu y I.G. Collado. J. Mol. Catalysis B: Enzymatic,70 (2011) 61–66

Non-peptide metabolites from Bacillus genus. A. Hamdache, A. Lamarti, J. Aleu y I.G. Collado. J. Nat. Prod. 2011, 74(4), 893-899

The Botrytis cinerea phytotoxin botcinic acid requires two polyketide synthases for production and has a redundant role in virulence with botrydial. Bérengère Dalmais, Julia Schumacher, Javier Moraga, Pascal le Pecheur, Bettina Tdzynski Isidro Gonzalez Collado, and Muriel Viaud. Molecular Plant Pathology 2011, 12(6), 564-579

Azaphilones from the endophyte Chaetomium globosum, Borges, Warley S.; Mancilla, Gabriela; Guimaraes, Denise O.; Duran-Patron, Rosa; Collado, Isidro G.; Pupo, Monica T. Journal of Natural Products 2011, 74(5), 1182-1187

Biotransformation of bioactive isocaryolanes by Botrytis cinerea.; Ascari, Jociani; Boaventura, Maria Amelia Diamantino; Takahashi, Jacqueline Aparecida; Duran-Patron, Rosa; Hernandez-Galan, Rosario; Macias-Sanchez, Antonio J.; Collado, Isidro G. Journal of Natural Products 2011, 74(8), 1707-1712.

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